1. Of persons or agents: Diligent, active, constant in application to the matter in hand; assiduous, persistent.
Hurtful or injurious to life or health; noxious.
Hatred of mankind; the character, nature, or condition of a misanthrope.
The profuse discharge from nose and eyes which generally accompanies a cold, and which was formerly supposed to run down from the brain; a ‘running at the nose’. Obs.